Porcine Carbonyl Reductase

Carbonyl reduction of mequindox by chicken and porcine cytosol and cloned carbonyl reductase 1.

Mequindox (MEQ) is a novel synthetic quinoxaline 1,4-dioxides derivative, which is widely used as a veterinary drug and animal feed additive. However, the metabolic mechanism of MEQ is rarely reported. The N-oxide reduction mechanism of MEQ was reported in our previous work. In this article, the toxicity and the reduction of the carbonyl of MEQ were studied. The 3-(4,5-dimethylthiazol-2-yl)-2,5...

Biphenyl Inhibitors of Carbonyl Reductase

Human carbonyl reductase 1 is an S-nitrosoglutathione reductase.

Human carbonyl reductase 1 (hCBR1) is an NADPH-dependent short chain dehydrogenase/reductase with broad substrate specificity and is thought to be responsible for the in vivo reduction of quinones, prostaglandins, and other carbonyl-containing compounds including xenobiotics. In addition, hCBR1 possesses a glutathione binding site that allows for increased affinity toward GSH-conjugated molecul...

Kinetic mechanism of pulmonary carbonyl reductase.

The kinetic mechanism of guinea-pig lung carbonyl reductase was studied at pH 7 in the forward reaction with five carbonyl substrates and NAD(P)H and in the reverse reaction with propan-2-ol and NAD(P)+. In each case the enzyme mechanism was sequential, and product-inhibition studies were consistent with a di-iso ordered bi bi mechanism, in which NAD(P)H binds to the enzyme first and NAD(P)+ le...

Dehydrogenase/Carbonyl Reductase Gene in Comamonas testosteroni

Wenjie Gong, Guangming Xiong, Edmund Maser* 5 6 Institute of Toxicology and Pharmacology for Natural Scientists, University Medical School, Schleswig7 Holstein, Campus Kiel, Brunswiker Strasse 10,D-24105 Kiel, Germany 8 9 *Corresponding author: Prof. Edmund Maser, Tel.: +49-431-597-3540; fax: +49-431-597-3558; 10 E-mail address: [email protected] (E. Maser) 11 12 Running Title: HsdR positi...